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PARP inhibitor olaparib increases the oncolytic activity of dl922‐947 in in vitro and in vivo model of anaplastic thyroid carcinoma

PARP inhibitors are mostly effective as anticancer drugs in association with DNA damaging agents. We have previously shown that the oncolytic adenovirus dl922‐947 induces extensive DNA damage, therefore we hypothesized a synergistic antitumoral effect of the PARP inhibitor olaparib in association wi...

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Библиографические подробности
Опубликовано в: :Mol Oncol
Главные авторы: Passaro, Carmela, Volpe, Massimiliano, Botta, Ginevra, Scamardella, Eloise, Perruolo, Giuseppe, Gillespie, David, Libertini, Silvana, Portella, Giuseppe
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528680/
https://ncbi.nlm.nih.gov/pubmed/25139258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.022
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