Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: Implications for the anti‐tumor barrier concept and treatment

The DNA damage response (DDR) machinery becomes commonly activated in response to oncogenes and during early stages of development of solid malignancies, with an exception of testicular germ cell tumors (TGCTs). The active DDR signaling evokes cell death or senescence but this anti‐tumor barrier can...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Bartkova, Jirina, Hoei-Hansen, Christina E., Krizova, Katerina, Hamerlik, Petra, Skakkebæk, Niels E., Rajpert-De Meyts, Ewa, Bartek, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528598/
https://ncbi.nlm.nih.gov/pubmed/25066726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.001
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