Erroneous class switching and false VDJ recombination: Molecular dissection of t(8;14)/MYC‐IGH translocations in Burkitt‐type lymphoblastic leukemia/B‐cell lymphoma

The chromosomal translocation t(8;14)(q24;q32) with juxtaposition of MYC to enhancer elements in the immunoglobulin heavy chain (IGH) gene locus is the genetic hallmark of the majority of Burkitt lymphoma and a subset of Diffuse large B‐cell lymphoma patients. Around 3% of adult B‐lineage acute lymp...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Burmeister, Thomas, Molkentin, Mara, Schwartz, Stefan, Gökbuget, Nicola, Hoelzer, Dieter, Thiel, Eckhard, Reinhardt, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528421/
https://ncbi.nlm.nih.gov/pubmed/23673335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.04.006
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