Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells

BACKGROUND: Our previous studies demonstrated that the class IA PI3K/p110β is critical in castration-resistant progression of prostate cancer (CRPC) and that targeting prostate cancer with nanomicelle-loaded p110β-specific inhibitor TGX221 blocked xenograft tumor growth in nude mice, confirming the...

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Bibliografske podrobnosti
izdano v:Prostate
Main Authors: He, Chenchen, Duan, Shaofeng, Dong, Liang, Wang, Yifen, Hu, Qingting, Liu, Chunjing, Forrest, M. Laird, Holzbeierlein, Jeffrey M., Han, Suxia, Li, Benyi
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527967/
https://ncbi.nlm.nih.gov/pubmed/28631436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23377
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