Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature

Poor tumor-targeted and cytoplasmic delivery is a bottleneck for protein toxin-based cancer therapy. Ideally, a protein toxin drug should remain stealthy in circulation for prolonged half-life and reduced side toxicity, but turn activated at tumor. PEGylation is a solution to achieve the first goal,...

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Publicado en:Biomaterials
Main Authors: Chen, Yingzhi, Zhang, Meng, Jin, Hongyue, Tang, Yisi, Wang, Huiyuan, Xu, Qin, Li, Yaping, Li, Feng, Huang, Yongzhuo
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527826/
https://ncbi.nlm.nih.gov/pubmed/27914267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.11.033
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