Role of AxyZ Transcriptional Regulator in Overproduction of AxyXY-OprZ Multidrug Efflux System in Achromobacter Species Mutants Selected by Tobramycin

AxyXY-OprZ is an RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. We investigated here a putative TetR family transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. An in-frame axyZ gene deletion assay led to increased MICs of ant...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Bador, Julien, Neuwirth, Catherine, Grangier, Nadège, Muniz, Marie, Germé, Leslie, Bonnet, Jérémy, Pillay, Vignesh-Guru, Llanes, Catherine, de Curraize, Claire, Amoureux, Lucie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2017
Onderwerpen:
Mechanisms of Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527583/
https://ncbi.nlm.nih.gov/pubmed/28584156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00290-17
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