Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Altered nuclear shape is a defining feature of cancer cells. The mechanisms underlying nuclear dysmorphia in cancer remain poorly understood. Here we identify PPP1R12A and PPP1CB, two subunits of the myosin phosphatase complex that antagonizes actomyosin contractility, as proteins safeguarding nucle...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Takaki, Tohru, Montagner, Marco, Serres, Murielle P., Le Berre, Maël, Russell, Matt, Collinson, Lucy, Szuhai, Karoly, Howell, Michael, Boulton, Simon J., Sahai, Erik, Petronczki, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527285/
https://ncbi.nlm.nih.gov/pubmed/28737169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16013
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