The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach

BACKGROUND: N-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to N-acetyl INH through a process of acetylation, and confers low-level resistance to INH in Mycobacterium tuberculosis (MTB). Similar to NAT of MTB, NAT2 in humans performs the same function of acetylation. Rapid acetyl...

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Publicado en:Tuberc Respir Dis (Seoul)
Autores principales: Unissa, Ameeruddin Nusrath, Sukumar, Swathi, Hanna, Luke Elizabeth
Formato: Artigo
Lenguaje:Inglês
Publicado: The Korean Academy of Tuberculosis and Respiratory Diseases 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526952/
https://ncbi.nlm.nih.gov/pubmed/28747958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4046/trd.2017.80.3.255
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