IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

BACKGROUND: The immunosuppression and immune dysregulation that follows severe injury includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and IL13 early after injury. We hypothesized that IL33, an alarmin released early after tissue injury and a known regulator of t...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Xu, Jing, Guardado, Jesse, Hoffman, Rosemary, Xu, Hui, Namas, Rami, Vodovotz, Yoram, Xu, Li, Ramadan, Mostafa, Brown, Joshua, Turnquist, Heth R., Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526517/
https://ncbi.nlm.nih.gov/pubmed/28742815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002365
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