Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

BACKGROUND: Transmembrane helices (TMHs) frequently occur amongst protein architectures as means for proteins to attach to or embed into biological membranes. Physical constraints such as the membrane’s hydrophobicity and electrostatic potential apply uniform requirements to TMHs and their flanking...

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Bibliographic Details
Published in:BMC Biol
Main Authors: Baker, James Alexander, Wong, Wing-Cheong, Eisenhaber, Birgit, Warwicker, Jim, Eisenhaber, Frank
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525207/
https://ncbi.nlm.nih.gov/pubmed/28738801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-017-0404-4
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