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Characterization of the steroid-metabolizing capacity of the hepatic cytochrome P450IIC5 expressed in COS-1 cells: 3 beta-hydroxysteroid dehydrogenase/delta 5----4 isomerase type activity.

Cytochrome P450IIC5 (rabbit liver 21-hydroxylase) is unusual among hepatic forms of cytochromes P450 because it catalyzes the conversion of one active steroid hormone (progesterone) to another active hormone (deoxycorticosterone). Another interesting aspect of this steroid-hydroxylating enzyme is th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Trant, J M, Lorence, M C, Johnson, E F, Shackleton, C H, Mason, J I, Estabrook, R W
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55252/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2148210/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.24.9756
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