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Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid

Several studies have shown that docosahexaenoic acid (DHA) attenuates epileptic seizures; however, the molecular mechanism by which it achieves this effect is still largely unknown. DHA stimulates the retinoid X receptor, which reportedly regulates the expression of cytochrome P450 aromatase (P450ar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ishihara, Yasuhiro, Itoh, Kouichi, Tanaka, Miki, Tsuji, Mayumi, Kawamoto, Toshihiro, Kawato, Suguru, Vogel, Christoph F. A., Yamazaki, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524681/
https://ncbi.nlm.nih.gov/pubmed/28740157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06630-0
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