MiR30‐GALNT1/2 Axis‐Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts

BACKGROUND: Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. T...

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Publicado en:J Am Heart Assoc
Autores principales: Nakagawa, Yasuaki, Nishikimi, Toshio, Kuwahara, Koichiro, Fujishima, Aoi, Oka, Shogo, Tsutamoto, Takayoshi, Kinoshita, Hideyuki, Nakao, Kazuhiro, Cho, Kosai, Inazumi, Hideaki, Okamoto, Hiroyuki, Nishida, Motohiro, Kato, Takao, Fukushima, Hiroyuki, Yamashita, Jun K., Wijnen, Wino J., Creemers, Esther E., Kangawa, Kenji, Minamino, Naoto, Nakao, Kazuwa, Kimura, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523735/
https://ncbi.nlm.nih.gov/pubmed/28188250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003601
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