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Fibrinolytic enzyme co-therapy improves tumor perfusion and therapeutic efficacy of anticancer nanomedicine

Elevated interstitial fluid pressure and solid stress within tumors contribute to poor intratumoral distribution of nanomedicine. In this study, we hypothesized that the presence of fibrin in tumor extracellular matrix contributes to hindered intratumoral distribution of nanocarriers and that this c...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Kirtane, Ameya R., Sadhukha, Tanmoy, Kim, Hyunjoon, Khanna, Vidhi, Koniar, Brenda, Panyam, Jayanth
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523511/
https://ncbi.nlm.nih.gov/pubmed/28108516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1646
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