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Do Halogen–Hydrogen Bond Donor Interactions Dominate the Favorable Contribution of Halogens to Ligand–Protein Binding?

[Image: see text] Halogens are present in a significant number of drugs, contributing favorably to ligand–protein binding. Currently, the contribution of halogens, most notably chlorine and bromine, is largely attributed to halogen bonds involving favorable interactions with hydrogen bond acceptors....

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Vydáno v:J Phys Chem B
Hlavní autoři: Lin, Fang-Yu, MacKerell, Alexander D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2017
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523114/
https://ncbi.nlm.nih.gov/pubmed/28657759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b04198
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