Enhanced tumor growth inhibition by mesenchymal stem cells derived from iPSCs with targeted integration of interleukin24 into rDNA loci

Induced pluripotent stem cells (iPSCs) are a promising source of mesenchymal stem cells (MSCs) for clinical applications. In this study, we transformed human iPSCs using a non-viral vector carrying the IL24 transgene pHrn-IL24. PCR and southern blotting confirmed IL24 integration into the rDNA loci...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Bo, Chen, Fei, Wu, Yong, Wang, Xiaolin, Feng, Mai, Li, Zhuo, Zhou, Miaojin, Wang, Yanchi, Wu, Lingqian, Liu, Xionghao, Liang, Desheng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522332/
https://ncbi.nlm.nih.gov/pubmed/28388559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16584
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