BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations

Deficient mismatch repair (MMR) and microsatellite instability (MSI) contribute to ~15% of colorectal cancer (CRCs). We hypothesized MSI leads to mutations in DNA repair proteins including BRCA2 and cancer drivers including EGFR. We analyzed mutations among a discovery cohort of 26 MSI-High (MSI-H)...

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Udgivet i:Oncotarget
Main Authors: Deihimi, Safoora, Lev, Avital, Slifker, Michael, Shagisultanova, Elena, Xu, Qifang, Jung, Kyungsuk, Vijayvergia, Namrata, Ross, Eric A., Xiu, Joanne, Swensen, Jeffrey, Gatalica, Zoran, Andrake, Mark, Dunbrack, Roland L., El-Deiry, Wafik S.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522275/
https://ncbi.nlm.nih.gov/pubmed/28591715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18098
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