Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses

STAT5 transcription factors are frequently activated in hematopoietic neoplasms and are targets of various tyrosine kinase oncogenes. Evidences for a crosstalk between STAT5 and reactive oxygen species (ROS) metabolism have recently emerged but mechanisms involved in STAT5-mediated regulation of ROS...

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Gepubliceerd in:Oncotarget
Hoofdauteurs: Bourgeais, Jerome, Ishac, Nicole, Medrzycki, Magdalena, Brachet-Botineau, Marie, Desbourdes, Laura, Gouilleux-Gruart, Valerie, Pecnard, Emmanuel, Rouleux-Bonnin, Florence, Gyan, Emmanuel, Domenech, Jorge, Mazurier, Frederic, Moriggl, Richard, Bunting, Kevin D., Herault, Olivier, Gouilleux, Fabrice
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522035/
https://ncbi.nlm.nih.gov/pubmed/27566554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11480
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