EFFECTS OF SODIUM THIOSULFATE VERSUS OBSERVATION ON DEVELOPMENT OF CISPLATIN-INDUCED HEARING LOSS IN CHILDREN WITH CANCER: RESULTS FROM THE CHILDREN’S ONCOLOGY GROUP ACCL0431 RANDOMISED CLINICAL TRIAL

BACKGROUND: Sodium thiosulfate (STS) is an antioxidant shown in preclinical studies to prevent cisplatin-induced hearing loss (CIHL) but not compromise anti-tumour efficacy with timed administration post-cisplatin. The primary study aim was to evaluate STS for prevention of CIHL. METHODS: ACCL0431 w...

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Vydáno v:Lancet Oncol
Hlavní autoři: Freyer, David R., Chen, Lu, Krailo, Mark D., Knight, Kristin, Villaluna, Doojduen, Bliss, Bonnie, Pollock, Brad H., Ramdas, Jagadeesh, Lange, Beverly, Van Hoff, David, VanSoelen, Michele L., Wiernikowski, John, Neuwelt, Edward A., Sung, Lillian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520988/
https://ncbi.nlm.nih.gov/pubmed/27914822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)30625-8
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