EFFECTS OF SODIUM THIOSULFATE VERSUS OBSERVATION ON DEVELOPMENT OF CISPLATIN-INDUCED HEARING LOSS IN CHILDREN WITH CANCER: RESULTS FROM THE CHILDREN’S ONCOLOGY GROUP ACCL0431 RANDOMISED CLINICAL TRIAL

BACKGROUND: Sodium thiosulfate (STS) is an antioxidant shown in preclinical studies to prevent cisplatin-induced hearing loss (CIHL) but not compromise anti-tumour efficacy with timed administration post-cisplatin. The primary study aim was to evaluate STS for prevention of CIHL. METHODS: ACCL0431 w...

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Detalhes bibliográficos
Publicado no:Lancet Oncol
Main Authors: Freyer, David R., Chen, Lu, Krailo, Mark D., Knight, Kristin, Villaluna, Doojduen, Bliss, Bonnie, Pollock, Brad H., Ramdas, Jagadeesh, Lange, Beverly, Van Hoff, David, VanSoelen, Michele L., Wiernikowski, John, Neuwelt, Edward A., Sung, Lillian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520988/
https://ncbi.nlm.nih.gov/pubmed/27914822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)30625-8
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