Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression

Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression. Known that CD44 has the specific binding sites for a natural ligand hyaluronan (HA), we investigated biological effects of H...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kasai, Shin, Furuichi, Yoshiyuki, Ando, Norie, Kagami, Keiko, Abe, Masako, Nakane, Takaya, Goi, Kumiko, Inukai, Takeshi, Saitoh, Sei, Ohno, Shinichi, Okazaki, Shogo, Nagano, Osamu, Saya, Hideyuki, Sugita, Kanji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520907/
https://ncbi.nlm.nih.gov/pubmed/28569787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.249
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