DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues

The E2F transcription factor 1 is subtly regulated along the cell cycle progression and in response to DNA damage by post-translational modifications. Here, we demonstrated that the E3-ubiquitin ligase cellular inhibitor of apoptosis 1 (cIAP1) increases E2F1 K63-poly-ubiquitination on the lysine res...

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Publicat a:Cell Death Dis
Autors principals: Glorian, Valérie, Allègre, Jennifer, Berthelet, Jean, Dumetier, Baptiste, Boutanquoi, Pierre-Marie, Droin, Nathalie, Kayaci, Cémile, Cartier, Jessy, Gemble, Simon, Marcion, Guillaume, Gonzalez, Daniel, Boidot, Romain, Garrido, Carmen, Michaud, Olivier, Solary, Eric, Dubrez, Laurence
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520736/
https://ncbi.nlm.nih.gov/pubmed/28542143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.222
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