The low-affinity Ca2(+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction.

Both troponin C (TnC) and calmodulin share a remarkably similar tertiary motif that may be common to other Ca2(+)-binding proteins with activator activity. TnC plays a critical role in regulating muscle contraction and is particularly well-suited for structural analysis by site-directed mutation. Fa...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Sweeney, H L, Brito, R M, Rosevear, P R, Putkey, J A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55207/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2263608/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.24.9538
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