Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma

Hepatitis B virus (HBV) and the closely related woodchuck hepatitis virus (WHV) are potent carcinogens that trigger development of primary hepatocellular carcinoma (HCC). The initial sites of hepadnavirus–host genome integration, their diversity and kinetics of formation can be central to virus pers...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Chauhan, R, Churchill, N D, Mulrooney-Cousins, P M, Michalak, T I
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520499/
https://ncbi.nlm.nih.gov/pubmed/28414318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.22
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