Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

Replication stress is a characteristic feature of cancer cells, which is resulted from sustained proliferative signaling induced by activation of oncogenes or loss of tumor suppressors. In cancer cells, oncogene-induced replication stress manifests as replication-associated lesions, predominantly do...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Kumar, S, Peng, X, Daley, J, Yang, L, Shen, J, Nguyen, N, Bae, G, Niu, H, Peng, Y, Hsieh, H-J, Wang, L, Rao, C, Stephan, C C, Sung, P, Ira, G, Peng, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520492/
https://ncbi.nlm.nih.gov/pubmed/28414320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.15
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