T-cell expression of AhR inhibits the maintenance of pT(reg) cells in the gastrointestinal tract in acute GVHD

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that affects the function and development of immune cells. Here, we show that recipient mice receiving AhR(−/−) T cells have improved survival and decreased acute graft-versus-host disease (aGVHD) in 2 different murine al...

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Udgivet i:Blood
Main Authors: Dant, Trisha A., Lin, Kaifeng L., Bruce, Danny W., Montgomery, Stephanie A., Kolupaev, Oleg V., Bommiasamy, Hemamalini, Bixby, Lisa M., Woosley, John T., McKinnon, Karen P., Gonzalez, Frank J., Blazar, Bruce R., Vincent, Benjamin G., Coghill, James M., Serody, Jonathan S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520467/
https://ncbi.nlm.nih.gov/pubmed/28550042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-734244
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