De novo active sites for resurrected Precambrian enzymes

Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed many different reactions already in the last universal common ancestor. Mechanisms for the emergence of completely new active sites must therefo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Risso, Valeria A., Martinez-Rodriguez, Sergio, Candel, Adela M., Krüger, Dennis M., Pantoja-Uceda, David, Ortega-Muñoz, Mariano, Santoyo-Gonzalez, Francisco, Gaucher, Eric A., Kamerlin, Shina C. L., Bruix, Marta, Gavira, Jose A., Sanchez-Ruiz, Jose M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520109/
https://ncbi.nlm.nih.gov/pubmed/28719578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16113
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