DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) bromodomain (BRD) has moderate specificity for H3K14ac. Surprisingly, we also find that both BRG1 and hBRM BRDs have DNA-bindi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Morrison, Emma A., Sanchez, Julio C., Ronan, Jehnna L., Farrell, Daniel P., Varzavand, Katayoun, Johnson, Jenna K., Gu, Brian X., Crabtree, Gerald R., Musselman, Catherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519978/
https://ncbi.nlm.nih.gov/pubmed/28706277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16080
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