Large-Scale Analysis of Drug Side Effects via Complex Regulatory Modules Composed of microRNAs, Transcription Factors and Gene Sets

Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs. Most of previous studies were focused on a single level...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Jia, Xiaodong, Jin, Qing, Liu, Xiangqiong, Bian, Xiusen, Wang, Yunfeng, Liu, Lei, Ma, Hongzhe, Tan, Fujian, Gu, Mingliang, Chen, Xiujie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519677/
https://ncbi.nlm.nih.gov/pubmed/28729650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06083-5
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