Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells

Ionizing radiation (IR) induces DNA double-strand breaks (DSBs), which are an initial step towards chromosomal aberrations and cell death. It has been suggested that there are individual differences in radiosensitivity within human populations, and that the variations in DNA repair genes might deter...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Royba, Ekaterina, Miyamoto, Tatsuo, Natsuko Akutsu, Silvia, Hosoba, Kosuke, Tauchi, Hiroshi, Kudo, Yoshiki, Tashiro, Satoshi, Yamamoto, Takashi, Matsuura, Shinya
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519549/
https://ncbi.nlm.nih.gov/pubmed/28729543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06393-8
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