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Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes
Kidney disease has been linked to dysregulated signaling via PKC in kidney cells such as podocytes. PKCα is a conventional isoform of PKC and a well-known binding partner of β-catenin, which promotes its degradation. β-Catenin is the main effector of the canonical Wnt pathway and is critical in cell...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5519362/ https://ncbi.nlm.nih.gov/pubmed/28539358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775700 |
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