Identification and characterization of C-terminal fragments of the beta-amyloid precursor produced in cell culture.

The mechanism of amyloid formation in Alzheimer's disease is unknown but appears to involve proteolytic processing of the amyloidogenic peptide from a larger precursor. When the C-terminus containing the amyloid-forming and cytoplasmic domains of the precursor was recombinantly expressed in cul...

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Bibliographic Details
Published in:EMBO J
Main Authors: Wolf, D, Quon, D, Wang, Y, Cordell, B
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC551925/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1694126/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb07375.x
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