Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation

HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits wild-type HIV-1 infection more potently than...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zhyvoloup, Alexander, Melamed, Anat, Anderson, Ian, Planas, Delphine, Lee, Chen-Hsuin, Kriston-Vizi, Janos, Ketteler, Robin, Merritt, Andy, Routy, Jean-Pierre, Ancuta, Petronela, Bangham, Charles R. M., Fassati, Ariberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519191/
https://ncbi.nlm.nih.gov/pubmed/28727807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006460
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