Hypoxia-inducible factor 1α is a critical downstream mediator for hypoxia-induced mitogenic factor (FIZZ1/RELMα)-induced pulmonary hypertension

OBJECTIVE: Pulmonary hypertension (PH) is characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown that in rodents, hypoxia-induced mitogenic factor (HIMF; also known as FIZZ1 or RELMα) causes PH by initiating lung vascul...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Johns, Roger A., Takimoto, Eiki, Meuchel, Lucas W., Elsaigh, Esra, Zhang, Ailan, Heller, Nicola M., Semenza, Gregg L., Yamaji-Kegan, Kazuyo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518796/
https://ncbi.nlm.nih.gov/pubmed/26586659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306710
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