Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi

Blue nevi are common melanocytic tumors arising in the dermal layer of the skin. Similar to uveal melanomas, blue nevi frequently harbor GNAQ and GNA11 mutations. Recently, recurrent CYSLTR2 and PLCB4 mutations were identified in uveal melanomas not harboring GNAQ or GNA11 mutations. All four genes...

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Udgivet i:Mod Pathol
Main Authors: Möller, Inga, Murali, Rajmohan, Müller, Hansgeorg, Wiesner, Thomas, Jackett, Louise A, Scholz, Simone L, Cosgarea, Ioana, van de Nes, Johannes AP, Sucker, Antje, Hillen, Uwe, Schilling, Bastian, Paschen, Annette, Kutzner, Heinz, Rütten, Arno, Böckers, Martin, Scolyer, Richard A, Schadendorf, Dirk, Griewank, Klaus G
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518680/
https://ncbi.nlm.nih.gov/pubmed/27934878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2016.201
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