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Antibody domain mutants demonstrate autonomy of the antigen binding site.

We have constructed derivatives of a lambda I light chain-bearing anti-(4-hydroxy,3-nitrophenyl)acetyl (NP) antibody which have the V regions exchanged between heavy chains and light chains of the kappa or lambda I type. These antibodies are assembled and secreted normally, and bind haptenic and mac...

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Detalhes bibliográficos
Main Authors: Simon, T, Rajewsky, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC551777/
https://ncbi.nlm.nih.gov/pubmed/2108860
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