Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection

HCV infection can decrease NAD(+)/NADH ratio, which could convert lipid metabolism to favor HCV replication. In hepatocytes, quinolinate phosphoribosyl transferase (QPRT) catabolizes quinolinic acid (QA) to nicotinic acid mononucleotide (NAMN) for de novo NAD synthesis. However, whether and how HCV...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Wang, Zhilong, Gao, Yanhang, Zhang, Chao, Hu, Haiming, Guo, Dongwei, Xu, Yi, Xu, Qiuping, Zhang, Weihong, Deng, Sisi, Lv, Pingyun, Yang, Yan, Ding, Yanhua, Li, Qingquan, Weng, Changjiang, Chen, Xinwen, Gong, Sitang, Chen, Hairong, Niu, Junqi, Tang, Hong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517448/
https://ncbi.nlm.nih.gov/pubmed/28724915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06254-4
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