Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology

BACKGROUND/OBJECTIVES: Targeted kinase inhibitors are an important class of agents in anticancer therapeutics, but their limited tolerability hampers their clinical performance. Identification of the molecular mechanisms underlying the development of adverse reactions will be helpful in establishing...

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Опубликовано в: :NPJ Syst Biol Appl
Главные авторы: Amemiya, Takahiro, Honma, Masashi, Kariya, Yoshiaki, Ghosh, Samik, Kitano, Hiroaki, Kurachi, Yoshihisa, Fujita, Ken-ichi, Sasaki, Yasutsuna, Homma, Yukio, Abernethy, Darrel R, Kume, Haruki, Suzuki, Hiroshi
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516806/
https://ncbi.nlm.nih.gov/pubmed/28725458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjsba.2015.5
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