Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings for hepatotoxicity (BBW-H) in product labeling. The precise mechanisms and risk factors for KI-induced hepatotoxicity are poorly understood. Here, the 31 KIs were test...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Zhang, Jun, Salminen, Alec, Yang, Xi, Luo, Yong, Wu, Qiangen, White, Matthew, Greenhaw, James, Ren, Lijun, Bryant, Matthew, Salminen, William, Papoian, Thomas, Mattes, William, Shi, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Organ Toxicity and Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515969/
https://ncbi.nlm.nih.gov/pubmed/28032146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1918-1
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