Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol

10-Chloromethyl-11-demethyl-12-oxo-calanolide (F18), an analog of calanolide A, is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1. Here, we report the metabolic profile and the results of associated biochemical studies of F18 in vitro and in vivo. The metabolites of F18 w...

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Publicat a:Front Pharmacol
Autors principals: Wu, Xiangmeng, Zhang, Qinghao, Guo, Jiamei, Jia, Yufei, Zhang, Ziqian, Zhao, Manman, Yang, Yakun, Wang, Baolian, Hu, Jinping, Sheng, Li, Li, Yan
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515859/
https://ncbi.nlm.nih.gov/pubmed/28769808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00479
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