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V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.

V(D)J [variable--(diversity)--joining] recombination is regulated developmentally, being restricted to cells of the early B- and T-lymphocyte lineages. In this report we show that recombination activity can also be regulated in response to chemical effectors. Compounds that increase intracellular cA...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Menetski, J P, Gellert, M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55157/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1701258/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9324
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