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Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity
Synaptic loss is a symptom of Alzheimer’s disease (AD) that is associated with the onset of cognitive decline and the loss of executive function. The strongest genetic risk factor for AD is the APOE4 allele, which results in both a greater risk of developing AD as well as an earlier age of onset of...
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| Publicado no: | Neuroreport |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5515487/ https://ncbi.nlm.nih.gov/pubmed/28542068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000000811 |
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