Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function

The classical renin–angiotensin system (RAS), known as the angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages including cognitive decline. On the other hand, the ACE2/Ang-(1–7)/Mas receptor axis has been highlighted as exerting antagonis...

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Vydáno v:NPJ Aging Mech Dis
Hlavní autoři: Wang, Xiao-Li, Iwanami, Jun, Min, Li-Juan, Tsukuda, Kana, Nakaoka, Hirotomo, Bai, Hui-Yu, Shan, Bao-Shuai, Kan-no, Harumi, Kukida, Masayoshi, Chisaka, Toshiyuki, Yamauchi, Toshifumi, Higaki, Akinori, Mogi, Masaki, Horiuchi, Masatsugu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515001/
https://ncbi.nlm.nih.gov/pubmed/28721275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjamd.2016.24
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