Intact piRNA pathway prevents L1 mobilization in male meiosis

The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defects. It remains unknown whether L1 expression simply highlights piRNA deficiency or actually drives the germ-ce...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Newkirk, Simon J., Lee, Suman, Grandi, Fiorella C., Gaysinskaya, Valeriya, Rosser, James M., Vanden Berg, Nicole, Hogarth, Cathryn A., Marchetto, Maria C. N., Muotri, Alysson R., Griswold, Michael D., Ye, Ping, Bortvin, Alex, Gage, Fred H., Boeke, Jef D., An, Wenfeng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514719/
https://ncbi.nlm.nih.gov/pubmed/28630288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701069114
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