The inward rectifier current inhibitor PA‐6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

BACKGROUND AND PURPOSE: The density of the inward rectifier current (I(K1)) increases in atrial fibrillation (AF), shortening effective refractory period and thus promoting atrial re‐entry. The synthetic compound pentamidine analogue 6 (PA‐6) is a selective and potent I(K1) inhibitor. We tested PA‐6...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Ji, Yuan, Varkevisser, Rosanne, Opacic, Dragan, Bossu, Alexandre, Kuiper, Marion, Beekman, Jet D M, Yang, Sihyung, Khan, Azinwi Phina, Dobrev, Dobromir, Voigt, Niels, Wang, Michael Zhuo, Verheule, Sander, Vos, Marc A, van der Heyden, Marcel A G
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513871/
https://ncbi.nlm.nih.gov/pubmed/28542844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13869
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