Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits

OBJECTIVE: Endothelial lipase (EL) is a key determinant in plasma HDL-C. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis....

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Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Wang, Chuan, Nishijima, Kazutoshi, Kitajima, Shuji, Niimi, Manabu, Yan, Haizhao, Chen, Yajie, Ning, Bo, Matsuhisa, Fumikazu, Liu, Enqi, Zhang, Jifeng, Chen, Y. Eugene, Fan, Jianglin
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513187/
https://ncbi.nlm.nih.gov/pubmed/28546217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309139
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