Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

BACKGROUND: Pancreatic cancer is a devastating disease that is characterized by persistent hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α, although both are critical for tumor cells to adapt to the hypoxic microenvironment. However, unlike the well-studie...

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Bibliografske podrobnosti
izdano v:Mol Cancer
Main Authors: Zhang, Qi, Lou, Yu, Zhang, Jingying, Fu, Qihan, Wei, Tao, Sun, Xu, Chen, Qi, Yang, Jiaqi, Bai, Xueli, Liang, Tingbo
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512744/
https://ncbi.nlm.nih.gov/pubmed/28705232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0689-5
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