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PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood. Here we show using the inositol polyphosphate 5′-phosphatase E (INPP5E) and the GTP-binding protein (Rheb) that ca...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512577/ https://ncbi.nlm.nih.gov/pubmed/27063844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11366 |
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