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Development and validation of LC-MS/MS methods for the measurement of ribociclib, a CDK4/6 inhibitor, in mouse plasma and Ringer’s solution and its application to a cerebral microdialysis study

An LC-MS/MS method to measure ribociclib in mouse plasma and Ringer’s solution was successfully developed and validated. Reverse phase chromatography was performed with gradient elution using C18 (100A, 50x4.6 mm, 3μ) and C8-A (50x 2.0 mm, 5 μ) columns for plasma and Ringer’s samples, respectively....

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Podrobná bibliografie
Vydáno v:J Chromatogr B Analyt Technol Biomed Life Sci
Hlavní autoři: Kala, Ashish, Patel, Yogesh T., Davis, Abigail, Stewart, Clinton F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512115/
https://ncbi.nlm.nih.gov/pubmed/28521250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2017.05.002
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