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Kinetic insights into the temperature dependence of DNA strand cleavage and religation by topoisomerase III from the hyperthermophile Sulfolobus solfataricus

All cellular organisms encode type IA topoisomerases which catalyze DNA topological changes essential for DNA transactions. However, the kinetics of the reaction catalyzed by these enzymes remains poorly characterized. Here we measured the rapid kinetics of template binding, cleavage and religation...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Zhang, Junhua, Pan, Bailong, Li, Zhimeng, Sheng Zhao, Xin, Huang, Li
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511271/
https://ncbi.nlm.nih.gov/pubmed/28710489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05837-5
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