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TNF signalling drives expansion of bone marrow CD4(+) T cells responsible for HSC exhaustion in experimental visceral leishmaniasis
Visceral leishmaniasis is associated with significant changes in hematological function but the mechanisms underlying these changes are largely unknown. In contrast to naïve mice, where most long-term hematopoietic stem cells (LT-HSCs; LSK CD150(+) CD34(-) CD48(-) cells) in bone marrow (BM) are quie...
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| Publicado no: | PLoS Pathog |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5510901/ https://ncbi.nlm.nih.gov/pubmed/28671989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006465 |
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